Potential antimalarial drug candidates
We used generative AI/ML methods to create a long list of antimalarial drug candidates, based on previous expertise by Open Source Malaria.
Predicted to be highly active
Then, we evaluated each drug candidate with a high-confidence predictive model for activity against the malaria parasite. We also considered synthetic accessibility of the compounds, as well as drug-like properties.
Selected for experiments
Finally, we selected a list of high-confidence compounds for experimental validation by the Open Source Malaria team. Experimental validation coming soon!